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Series GSE41039 Query DataSets for GSE41039
Status Public on Nov 15, 2012
Title Control vs. PGISp spine samples
Organism Mus musculus
Experiment type Expression profiling by array
Summary OBJECTIVES: Ankylosing spondylitis (AS) is unique in its pathology where inflammation commences at the entheses before progressing to an osteoproliferative phenotype generating excessive bone formation that can result in joint fusion. The underlying mechanisms of this progression are poorly understood. Using the proteoglycan-induced spondylitis mouse (PGISp) model which displays spondylitis and eventual joint fusion following an initial inflammatory stimulus, we have characterised the structural and molecular changes that underlie disease progression
METHODS: PGISp mice were characterised 12 weeks after initiation of inflammation using expression profiling.
RESULTS: Microarray profiling showed genes involved in inflammation and immune-regulation were altered. Further, a number of genes specifically involved in bone regulation including other members of the Wnt pathway were also dysregulated.
CONCLUSION: This study implicates the Wnt pathway as a likely mediator of the mechanism by which inflammation induces bony ankylosis in spondyloarthritis, raising the potential that therapies targeting this pathway may be effective in preventing this process.
 
Overall design 4 unaffected spines vs. 4 spines from PGISp-affected mice
 
Contributor(s) Thomas G
Citation(s) 23171658
Submission date Sep 20, 2012
Last update date Jun 14, 2018
Contact name Gethin Thomas
E-mail(s) gethin.thomas@uq.edu.au
Phone +61 7 3176 2755
Fax +61 7 3176 5946
Organization name University of Queensland Diamantina Institute
Street address Princess Alexandra Hospital
City Woolloongabba
State/province QLD
ZIP/Postal code 4102
Country Australia
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM1007864 5388438026_A
GSM1007865 5388438026_B
GSM1007866 5388438026_C
Relations
BioProject PRJNA177733

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41039_RAW.tar 3.1 Mb (http)(custom) TAR
GSE41039_non-normalized.txt.gz 877.3 Kb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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