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| Status |
Public on Nov 13, 2006 |
| Title |
Gene expression changes resulting from cdc25a over-expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumorigenesis induced by expression of ras or neu. CDC25A- overexpressing tumors display aggressiveness and genomic instability with changes in fragile chromosomal regions, including the region orthologous to human 1p32-36.
Keywords: genetic modification
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| Overall design |
Tumors from two mice from each of two conditions (MMTV-cdc25a;MMTV-neu and MMTV-neu) were analyzed in a dye swap experiment. A total of four hybridizations were performed.
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| |
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| Contributor(s) |
Fuhrken PG, Kiyokawa H, Papoutsakis ET, Ray D |
| Citation(s) |
17283130 |
| Submission date |
Jan 28, 2006 |
| Last update date |
Dec 06, 2012 |
| Contact name |
Eleftherios Terry Papoutsakis |
| E-mail(s) |
papoutsakis@dbi.udel.edu
|
| Organization name |
University of Delaware
|
| Department |
Chemical Engineering
|
| Street address |
15 Innovation Way
|
| City |
Newark |
| State/province |
DE |
| ZIP/Postal code |
19711 |
| Country |
USA |
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| Platforms (1) |
| GPL2872 |
Agilent-012694 Whole Mouse Genome G4122A (Feature Number version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA94927 |
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