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Series GSE41229 Query DataSets for GSE41229
Status Public on Sep 30, 2012
Title Expression data from T-cells isolated from healthy mice or mice with polyposis
Organism Mus musculus
Experiment type Expression profiling by array
Summary There is much controversy about the role of T-regulatory cells (Treg) in human colon cancer. High densities of tumor-infiltrating Treg can correlate with better or worse clinical outcomes depending on the sutdy. Treg have potent anti-inflammatory functions that have been shown to control cancer progression. However, Treg isolated from patient with colon cancer or in mouse models of polyposis do not have the ability to suppress inflammation and instead promote cancer. Gene expression was preformed to determine differences between Treg isolated from healthy mice and Treg isolated from polyp-ridden mice.
 
Overall design Treg (CD4+Foxp3-GFP+) and CD4+ non-Treg (CD4+Foxp3-GFP-) were isolated from various organs of healthy Foxp3-GFP reporter mice or polyp-ridden Foxp3-GFPxAPCΔ468 reporter mice
 
Contributor(s) Blatner NR, Ericson J, Khazaie K, Benoist C, Gounari F, Rothamel K
Citation(s) 23241743, 24574339
Submission date Sep 29, 2012
Last update date Mar 04, 2019
Contact name Nichole Blatner
E-mail(s) nichole-blatner@northwestern.edu
Phone 312-503-1905
Fax 312-503-0386
Organization name Northwestern University
Department Robert H. Lurie Comprehensive Cancer Center
Lab Khazaie Lab
Street address 303 East Superior Street, Lurie 3-250
City Chicago
State/province IL
ZIP/Postal code 60611
Country USA
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (44)
GSM1011464 Foxp3-GFP mesenteric lymph node Treg, biological rep 1
GSM1011465 Foxp3-GFP mesenteric lymph node CD4+ non-Treg, biological rep 1
GSM1011466 Foxp3-GFP small intestine Treg, biological rep 1
Relations
BioProject PRJNA176269

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41229_RAW.tar 181.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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