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Series GSE41312 Query DataSets for GSE41312
Status Public on Oct 01, 2013
Title Modeling Pathogenesis of Primary Liver Cancer in Lineage Specific Cell Types
Organism Mus musculus
Experiment type Expression profiling by array
Summary Classification of human liver cancer into biologically distinct subgroups suggests origin from different hepatic lineage cells. To clarify contribution of lineage stage in liver oncogenesis, we transduced H-Ras and SV40LT into hepatic progenitor cells (HPC), hepatoblasts (HB) and terminally differentiated adult hepatocytes (AH). Regardless of origin, all transformed cell types acquired common cancer stem cell characteristics in vitro and in vivo. However, expression analysis distinguished tumors of different cellular origin underscoring the contribution of lineage/stage-dependent genetic changes in malignant transformation. Notably, AH-derived tumors showed specific enrichment of c-Myc target genes. These data establish that any hepatic lineage cell can be a target for transformation and acquire common cancer stem cell traits via activation of diverse cell type specific pathways.
 
Overall design Profiling of individual tumors derived by Ras/SV40 transformation of hepatic progenitor cell (oval cells), hepatoblasts (fetal) and adult hepatocytes
 
Contributor(s) Andersen JB, Holczbauer A, Thorgeirsson SS
Citation(s) 23523670
Submission date Oct 03, 2012
Last update date Jun 14, 2018
Contact name Jesper B Andersen
Organization name Copenhagen University
Department Biotech Research and Innovation Centre
Lab Andersen Group
Street address Ole Maaloes Vej 5
City Copenhagen
ZIP/Postal code 2200
Country Denmark
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (62)
GSM1014446 hepatc progenitor cell derived tumor [HPC1]
GSM1014447 hepatc progenitor cell derived tumor [HPC2]
GSM1014448 hepatc progenitor cell derived tumor [HPC3]
Relations
BioProject PRJNA176489

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41312_RAW.tar 3.1 Mb (http)(custom) TAR
GSE41312_non-normalized.txt.gz 9.4 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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