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Series GSE41355 Query DataSets for GSE41355
Status Public on Apr 23, 2013
Title IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Organism Mus musculus
Experiment type Expression profiling by array
Summary Myeloid dendritic cells from WT, Irf3-/-xIrf7-/-, Irf3-/-xIrf5-/-xIrf7-/-, Mavs-/- (IPS1-/-)and Ifnar-/- mice were infected with West Nile virus to assess the contributions of specific signaling and transcription factors in initiating the antiviral response
 
Overall design RPMI + rmGM-CSF purified bone marrow derived myeloid DC (mDC), mock and WNV infected with insect derived virus and RNA isolated at 24 hours post infection . Each genotype has matched mock and infected samples. n=6 for WT mock, WT infected, IFNAR mock, IFNAR infected, IRF3x7 infected; n=5 IRF3x7 infected; n=3 IRF3x5x7 mock, IRF3x5x7 infected, MAVS mock, MAVS infected. RNA was prepared using the Illumina bead station assay and hybridized to Illumina RefSeq-8 V2 BeadChips. Note: MAVS=IPS1
 
Contributor(s) Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray L, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, GaleJr M, Fruh K, Diamond MS, Wilkinson PA
Citation(s) 23300459
Submission date Oct 04, 2012
Last update date Jun 14, 2018
Contact name Peter A Wilkinson
Organization name Case Western Reserve University
Department Pathology / Systems Biology & Bioinformatics
Street address 2103 Cornell Road
City Cleveland
State/province Ohio
ZIP/Postal code 44120
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (29)
GSM1015414 WT 1a
GSM1015415 WT 1b
GSM1015416 WT 2a
Relations
BioProject PRJNA176623

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41355_RAW.tar 7.9 Mb (http)(custom) TAR (of TXT)
GSE41355_non-normalized.txt.gz 1.2 Mb (ftp)(http) TXT
Raw data provided as supplementary file
Processed data included within Sample table
Raw data are available on Series record

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