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Series GSE41363 Query DataSets for GSE41363
Status Public on Oct 06, 2012
Title Role of the Cytoskeleton in muscle transcriptional response to altered use
Organism Mus musculus
Experiment type Expression profiling by array
Summary Desmin is a cytoskeletal protein in muscle involved in integrating cellular space and transmitting forces. In this study we sought to determine the combinatory effects of desmin deletion, aging and eccentric exercise on skeletal muscle at the transcriptional level across many pathways of muscle physiology.
 
Overall design RNA was isolated from the TA muscle of mice of two genotypes (wildtype (WT) and desmin knockout (KO)) and two ages (7-9 weeks (Adult) and 12-14 months (Aged)). TA muscles were subjected to a bout of 50 eccentric contractions 12 hours prior to RNA isolation. Numbers per group are as follows: WT_Adult (5), WT_Aged (5), KO_Adult (5), KO_Aged (4).
 
Contributor(s) Meyer GA, Lieber RL
Citation(s) 23444318
Submission date Oct 05, 2012
Last update date May 04, 2018
Contact name Gretchen Meyer
Organization name University of California San Diego
Department Bioengineering
Street address 9500 Gilman Dr
City La Jolla
State/province CA
ZIP/Postal code 92122
Country USA
 
Platforms (1)
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (19)
GSM1015522 Muscle 50 eccentric contractions 12 hours WT Adult 0629
GSM1015523 Muscle 50 eccentric contractions 12 hours WT Adult 0701
GSM1015524 Muscle 50 eccentric contractions 12 hours WT Adult 07271
Relations
BioProject PRJNA176690

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41363_RAW.tar 37.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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