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Series GSE41581 Query DataSets for GSE41581
Status Public on Jun 30, 2013
Title Frequent truncating mutations of STAG2 in bladder cancer
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.

Affymetrix CytoScan HD Arrays were performed according to the manufacturer's directions on genomic DNA extracted directly from 12 snap-frozen human urothelial carcinoma primary tumors with somatic mutations of the STAG2 gene.
 
Overall design Copy number analysis using Affymetrix CytoScan HD Arrays was performed for 12 human urothelial carcinomas of the bladder with truncating mutations of the STAG2 gene.
 
Contributor(s) Solomon DA, Waldman T, Elkahloun A
Citation(s) 24121789
Submission date Oct 15, 2012
Last update date Jul 13, 2018
Contact name David A. Solomon
E-mail(s) david.solomon@ucsfmedctr.org
Organization name University of California, San Francisco
Department Pathology
Street address 513 Parnassus Ave, HSW 450
City San Francisco
State/province CA
ZIP/Postal code 94143
Country USA
 
Platforms (1)
GPL16131 [CytoScanHD_Array] Affymetrix CytoScan HD Array
Samples (12)
GSM1019673 MDACC 10057
GSM1019674 MDACC 10059
GSM1019675 MDACC 10076
Relations
BioProject PRJNA177576

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41581_RAW.tar 1.3 Gb (http)(custom) TAR (of CEL, CYCHP)
Processed data included within Sample table
Processed data provided as supplementary file

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