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Series GSE41720 Query DataSets for GSE41720
Status Public on Dec 11, 2012
Title OGT, H2B S112GlcNAc, TET2 ChIP-seq results
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary TET2 directly interacts with OGT, which is important for the chromatin association of OGT in vivo. Although this specific interaction does not regulate the enzymatic activity of TET2, it facilitates OGT-dependent histone O-GlcNAcylation. Moreover, OGT associates with TET2 at transcription starting sites (TSS). Down-regulation of TET2 reduces the amount of H2B S112 GlcNAc marks in vivo, which are associated with gene transcription regulation.
 
Overall design We found that OGT interacts with TET2 tightly. Using ChIP-seq with specific antibodies, we tested the co-localization of TET2 and OGT in genome level.
 
Contributor(s) Chen Q, Yu X, Chen Y, Bian C
Citation(s) 23222540
Submission date Oct 19, 2012
Last update date May 15, 2019
Contact name qiang chen
Organization name umich
Street address 1150 W. medical school road
City Ann arbor
State/province Michigan
ZIP/Postal code 48104
Country USA
 
Platforms (1)
GPL9185 Illumina Genome Analyzer (Mus musculus)
Samples (3)
GSM1023124 TET2 ChIP-seq results
GSM1023125 OGT ChIP-seq results
GSM1023126 H2B S112 GlcNAc ChIP-seq results
This SubSeries is part of SuperSeries:
GSE41722 TET2 KD and ChIP-Seq
Relations
BioProject PRJNA178017
SRA SRP016566

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41720_RAW.tar 166.0 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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