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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 01, 2013 |
| Title |
Senescence gene signature of radiation fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Radiation lung injury is characterized by early inflammation and late fibrosis. The causes underlying the chronic, progressive nature of radiation injury are poorly understood. Here, we report that the gene expression of irradiated lung tissue correlates with that observed in the lungs in aged animals. We demonstrate that NOX4 expression and superoxide elaboration is increased in irradiated lungs and pneumocytes in a dose dependent fashion.
We used microarrays to detail the global programme of gene expression and report that irradiated lung tissue correlates with that observed in the lungs in aged animals.
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| Overall design |
Female C57Bl/Ncr mice, aged 10 weeks were treated with/ without radiation to the thorax with a X-RAD 320 x-ray irradiator at a dose rate of 2.61 Gy/minute. An age-matched cohort of mice received no IR while additional cohorts received 5 Gy in a single dose, 17.5 Gy in a single dose. RNA was extracted and hybridization done on Affymetrix Mouse430_2 microarrays.
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| Contributor(s) |
Citrin D, Chung EJ |
| Citation(s) |
24052614 |
| Submission date |
Oct 23, 2012 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Uma T Shankavaram |
| E-mail(s) |
uma@mail.nih.gov
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| Phone |
301-496-6718
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| Organization name |
NIH
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| Department |
NCI
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| Lab |
Radiation Oncology Branch
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| Street address |
9000 Rockville Pike
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (45)
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| GSM1024320 |
mouse lung tissue at week 2, 0 Gy, biological rep1 |
| GSM1024321 |
mouse lung tissue at week 2, 0 Gy, biological rep2 |
| GSM1024322 |
mouse lung tissue at week 2, 0 Gy, biological rep3 |
| GSM1024323 |
mouse lung tissue at week 2, 5Gy, biological rep1 |
| GSM1024324 |
mouse lung tissue at week 2, 5Gy, biological rep2 |
| GSM1024325 |
mouse lung tissue at week 2, 5Gy, biological rep3 |
| GSM1024326 |
mouse lung tissue at week 2, 17.5 Gy, biological rep1 |
| GSM1024327 |
mouse lung tissue at week 2, 17.5 Gy, biological rep2 |
| GSM1024328 |
mouse lung tissue at week 2, 17.5 Gy, biological rep3 |
| GSM1024329 |
mouse lung tissue at week 4, 0 Gy, biological rep1 |
| GSM1024330 |
mouse lung tissue at week 4, 0 Gy, biological rep2 |
| GSM1024331 |
mouse lung tissue at week 4, 0 Gy, biological rep3 |
| GSM1024332 |
mouse lung tissue at week 4, 5Gy, biological rep1 |
| GSM1024333 |
mouse lung tissue at week 4, 5Gy, biological rep2 |
| GSM1024334 |
mouse lung tissue at week 4, 5Gy, biological rep3 |
| GSM1024335 |
mouse lung tissue at week 4, 17.5 Gy, biological rep1 |
| GSM1024336 |
mouse lung tissue at week 4, 17.5 Gy, biological rep2 |
| GSM1024337 |
mouse lung tissue at week 4, 17.5 Gy, biological rep3 |
| GSM1024338 |
mouse lung tissue at week 8, 0 Gy, biological rep1 |
| GSM1024339 |
mouse lung tissue at week 8, 0 Gy, biological rep2 |
| GSM1024340 |
mouse lung tissue at week 8, 0 Gy, biological rep3 |
| GSM1024341 |
mouse lung tissue at week 8, 5Gy, biological rep1 |
| GSM1024342 |
mouse lung tissue at week 8, 5Gy, biological rep2 |
| GSM1024343 |
mouse lung tissue at week 8, 5Gy, biological rep3 |
| GSM1024344 |
mouse lung tissue at week 8, 17.5 Gy, biological rep1 |
| GSM1024345 |
mouse lung tissue at week 8, 17.5 Gy, biological rep2 |
| GSM1024346 |
mouse lung tissue at week 8, 17.5 Gy, biological rep3 |
| GSM1024347 |
mouse lung tissue at week 16, 0 Gy, biological rep1 |
| GSM1024348 |
mouse lung tissue at week 16, 0 Gy, biological rep2 |
| GSM1024349 |
mouse lung tissue at week 16, 0 Gy, biological rep3 |
| GSM1024350 |
mouse lung tissue at week 16, 5Gy, biological rep1 |
| GSM1024351 |
mouse lung tissue at week 16, 5Gy, biological rep2 |
| GSM1024352 |
mouse lung tissue at week 16, 5Gy, biological rep3 |
| GSM1024353 |
mouse lung tissue at week 16, 17.5 Gy, biological rep1 |
| GSM1024354 |
mouse lung tissue at week 16, 17.5 Gy, biological rep2 |
| GSM1024355 |
mouse lung tissue at week 16, 17.5 Gy, biological rep3 |
| GSM1024356 |
mouse lung tissue at week 30, 0 Gy, biological rep1 |
| GSM1024357 |
mouse lung tissue at week 30, 0 Gy, biological rep2 |
| GSM1024358 |
mouse lung tissue at week 30, 0 Gy, biological rep3 |
| GSM1024359 |
mouse lung tissue at week 30, 5Gy, biological rep1 |
| GSM1024360 |
mouse lung tissue at week 30, 5Gy, biological rep2 |
| GSM1024361 |
mouse lung tissue at week 30, 5Gy, biological rep3 |
| GSM1024362 |
mouse lung tissue at week 30, 17.5 Gy, biological rep1 |
| GSM1024363 |
mouse lung tissue at week 30, 17.5 Gy, biological rep2 |
| GSM1024364 |
mouse lung tissue at week 30, 17.5 Gy, biological rep3 |
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| Relations |
| BioProject |
PRJNA178206 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE41789_RAW.tar |
176.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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