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Series GSE41941 Query DataSets for GSE41941
Status Public on Nov 01, 2012
Title Neutrophils play a key role in schistosome-induced hepatic granuloma formation
Organism Mus musculus
Experiment type Expression profiling by array
Summary The severity of schistosome egg-induced hepatic granulomatous pathology depends markedly on the nature of the mammalian host immune response. The local cellular and molecular mechanisms that co-ordinate hepatic granuloma formation during schistosome infection are still poorly understood. We used a combination of laser microdissection microscopy and microarray analysis to further our understanding of fibrogenesis and granuloma formation in C57BL/6 mice infected with Schistosoma japonicum. We compared hepatic gene expression profiles in histologically distinct zones both within, and directly proximal to, granulomas during the course of their development.
Overall design Defined zones of granulomas develop in the murine liver infected by Schistosoma japonicum over a period of 4, 6 and 7 weeks post infection were microdissected, and subjected to total RNA isolation and gene expression analysis. Microarray analysis of this study was performed using samples derived from 2 individual mice per group/time-point.
Contributor(s) Chuah C, Jones MK, Gobert GN
Citation(s) 23709687
Submission date Oct 31, 2012
Last update date Jun 14, 2018
Contact name Geoffrey Gobert
Organization name QIMR
Street address 300 Herston Rd
City Brisbane
ZIP/Postal code 4006
Country Australia
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (16)
GSM1027923 Liver uninfected control rep1
GSM1027924 Liver uninfected control rep2
GSM1027925 Granuloma 4 weeks rep1
BioProject PRJNA178550

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41941_RAW.tar 3.1 Mb (http)(custom) TAR
GSE41941_non-normalized.txt.gz 1.7 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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