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| Status |
Public on Jan 11, 2013 |
| Title |
Immune and tumor cell gene expression from node positive and node negative breast cancers' primary tumor, lymph nodes and peripheral blood |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of purified immune and breast tumor cells from three major compartments where cancer and immune cells interact: primary tumor, tumor draining lymph nodes (tumor invaded or tumor free), and peripheral blood. The results suggests that node-positive patients’ immune regulation and functionality is down-regulated compared to node-negative patients.
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| Overall design |
CD45+ Immune and ESA+ tumor cells were purified from breast cancer patients' primary tumor, tumor-draining lymph node, and peripheral blood (ficoll) and placed onto Agilent microarrays using the dye-swap method. A universal human reference was used as a reference for the patient samples.
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| |
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| Contributor(s) |
Yu H, Simons DL, Lee PP |
| Citation(s) |
23251464, 23136075 |
| Submission date |
Nov 01, 2012 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Peter P Lee |
| Organization name |
City of Hope
|
| Department |
Cancer Immunotherapeutics and Tumor Immunology
|
| Street address |
1500 E Duarte Rd.
|
| City |
Duarte |
| State/province |
CA |
| ZIP/Postal code |
91010 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (102)
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| Relations |
| BioProject |
PRJNA178662 |
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