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Series GSE420

Query DataSets for GSE420

Status

Public on Aug 28, 2003

Title

Aortic stiffness

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression with quantitative physiological parameters. METHODS AND RESULTS: In this study, we have used this approach to examine genes whose expression correlates with arterial stiffness in human aortic specimens. Our data identify 2 distinct groups of genes, those associated with cell signaling and those associated with the mechanical regulation of vascular structure (cytoskeletal-cell membrane-extracellular matrix). Although previous studies have concentrated on the contribution of the latter group toward arterial stiffness, our data suggest that changes in expression of signaling molecules play an equally important role. Alterations in the profiles of signaling molecules could be involved in the regulation of cell cytoskeletal organization, cell-matrix interactions, or the contractile state of the cell. CONCLUSIONS: Although the influence of smooth muscle contraction/relaxation on arterial stiffness could be controversial, our provocative data would suggest that further studies on this subject are indicated.
Keywords: other

Contributor(s)

Laurent S, Pratt R

Citation(s)

14530203

Submission date

Apr 30, 2003

Last update date

Dec 13, 2018

Contact name

Richard E. Pratt

E-mail(s)

rpratt@rics.bwh.harvard.edu