|
| Status |
Public on Jun 01, 2013 |
| Title |
The innate and adaptive immune response to BCG stimulation in splenocytes taken from C57BL/6 mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this experiment was to investigate differential gene expression in splenocytes stimulated with BCG from naïve and BCG vaccinated mice. The differences between naïve and BCG vaccinated mice might indicate the mechanisms by which BCG vaccination confers an enhanced ability of splenocytes from BCG vaccinated mice to inhibit growth of BCG in splenocyte cultures as compared with splenocytes from naive animals.
|
| |
|
| Overall design |
Splenocytes from 4 naïve and 4 BCG vaccinated female C57bl/6 mice were cultured for 12 hours with BCG (MOI 1:1) or without (unstimulated control). Each animal had a stimulated and an unstimulated sample hybridised to a beadchip.
|
| |
|
| Contributor(s) |
Marsay L, Fletcher HE, Kostov M, McShane H |
| Citation(s) |
23726784 |
| Submission date |
Nov 06, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
leanne marsay |
| E-mail(s) |
Leanne.marsay@ndm.ox.ac.uk
|
| Phone |
01865 857445
|
| Organization name |
University of Oxford
|
| Department |
Nuffield department
|
| Lab |
Jenner Institute
|
| Street address |
roosevelt drive
|
| City |
Oxford |
| ZIP/Postal code |
OX4 3TU |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA179104 |
Less...
More...