|
| Status |
Public on Nov 09, 2012 |
| Title |
Mechanism of cell death induced by saporin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1
These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av. Delivery of saporin into cancer cells by ch128.1Av, induces a transcriptional response consistent with oxidative stress and DNA damage, a response that is not observed with ch128.1Av alone.
|
| |
|
| Overall design |
Time course, after delivery of saporin into cells by ch128.1Av
|
| |
|
| Contributor(s) |
Penichet ML, Daniels TR |
| Citation(s) |
23085102 |
| Submission date |
Nov 08, 2012 |
| Last update date |
Nov 15, 2012 |
| Contact name |
Manuel Penichet |
| E-mail(s) |
penichet@mednet.ucla.edu
|
| Phone |
+1-310-825-1304
|
| Fax |
+1-310-825-7575
|
| Organization name |
University of California, Los Angeles
|
| Department |
Department of Surgery
|
| Lab |
Division of Surgical Oncology
|
| Street address |
Box 951782
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095-1782 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6255 |
Illumina humanRef-8 v2.0 expression beadchip |
|
| Samples (17)
|
|
| Relations |
| BioProject |
PRJNA179198 |
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