|
| Status |
Public on Aug 06, 2013 |
| Title |
Global DNA Hypermethylation in Down Syndrome Placenta [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We have performed genome-wide DNA methylation analysis at single base resolution and gene expression analysis, resulted in hypermethylation in all autosomes in DS samples, mediated by down-regulation of all three TET family genes, and down-regulation of REST/NRSF. Genes located on chr21 were up-regulated by a median of 45% in DS compared to normal villi, while genes with promoter hypermethylation were down regulated.
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| |
|
| Overall design |
Comparison of RNA expression in human placenta between 5 normal and 4 Trisomy 21 samples.
|
| |
|
| Contributor(s) |
Ding C |
| Citation(s) |
23754950 |
| Submission date |
Nov 08, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Chunming Ding |
| E-mail(s) |
cmding@gmail.com
|
| Organization name |
Wenzhou Medical University
|
| Street address |
School of Laboratory Medicine and Life Sciences
|
| City |
Wenzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
325035 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
|
| Samples (9)
|
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| This SubSeries is part of SuperSeries: |
| GSE42144 |
Global DNA Hypermethylation in Down Syndrome Placenta |
|
| Relations |
| BioProject |
PRJNA179205 |
| SRA |
SRP017123 |
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