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Series GSE42328 Query DataSets for GSE42328
Status Public on Aug 02, 2013
Title Gene Expression Profile of 53 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To analyze the prognostic relevance of transcriptional profiling in adult T-ALL, we analyzed a clinical series of 53 primary leukemia samples uniformly treated according to the ECOG E2993 protocol using gene expression oligonucleotide microarrays. Unsupervised analysis and consensus clustering of microarray gene expression data in this series revealed the presence of 2 stable gene expression clusters corresponding to early immature (n = 28) and cortical/mature (n = 25) adult T-ALLs respectively. Early immature T-ALLs show a gene expression signature related to hematopoietic stem cells and myeloid progenitors that was recently linked to a group of childhood T-ALLs with poor prognosis. Notably, univariate analysis in our patient series confirmed that early immature adult T-ALL is associated with poor prognosis and reduced overall survival compared with cortical/mature adult T-ALL (P = 0.0197)
 
Overall design 53 adult T-ALL samples were analyzed
 
Contributor(s) Van Vlierberghe P, Ambesi-Impiombato A, Rigo I, Hadler M, Paietta E, Wiernik PH, Rowe JM, Rue M, Ferrando AA
Citation(s) 23687089
Submission date Nov 15, 2012
Last update date Aug 13, 2018
Contact name Alberto Ambesi-Impiombato
Organization name Columbia University
Department ICG
Street address 1130 St. Nicholas Avenue
City New York
State/province NY
ZIP/Postal code 10032
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (53)
GSM1037879 lymphoblast T-ALL sample #1
GSM1037880 lymphoblast T-ALL sample #2
GSM1037881 lymphoblast T-ALL sample #3
Relations
BioProject PRJNA181086

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42328_RAW.tar 26.2 Mb (http)(custom) TAR
GSE42328_non-normalized.txt.gz 5.7 Mb (ftp)(http) TXT
Processed data included within Sample table

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