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Series GSE42464 Query DataSets for GSE42464
Status Public on Dec 15, 2014
Title Lung gene expression analysis of WT, Nlrp3-, Asc-deficient mice in Streptococcus pneumoniae D39 and ATCC6303 infection
Organism Mus musculus
Experiment type Expression profiling by array
Summary Streptococcus (S.) pneumoniae is the most frequently isolated causative pathogen community-acquired pneumonia, a leading cause of mortality worldwide. We investigated the role of the inflammasome sensor NLRP3 and the inflammasome adapter ASC during S. pneumoniae pneumonia. Detailed analysis of the early inflammatory response in the lung by whole genome transcriptional profiling, we identified several mediators that were differentially expressed between Nlrp3-/- and Asc-/ - mice.
 
Overall design WT, Nlrp3- and Asc-deficient mice were intranasally inocculated with Streptococcus pneumoniae D39 and ATCC6303 both at high and low dose. Lung homogenates were harvested and gene expression profiling was performed.
 
Contributor(s) Scicluna BP, van der Poll T
Citation(s) 24164497, 25998510
Submission date Nov 21, 2012
Last update date Jul 29, 2019
Contact name Brendon Paul Scicluna
E-mail(s) b.scicluna@amsterdamumc.nl
Organization name Academic Medical Center
Street address Meibergdreef 9
City Amsterdam
ZIP/Postal code 1105AZ
Country Netherlands
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (64)
GSM1040581 lung_AscKO_6303_High_6hrs_1
GSM1040582 lung_AscKO_6303_High_6hrs_2
GSM1040583 lung_AscKO_6303_High_6hrs_3
Relations
BioProject PRJNA182017

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42464_RAW.tar 3.1 Mb (http)(custom) TAR
GSE42464_non-normalized.txt.gz 10.9 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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