|
| Status |
Public on Jan 22, 2013 |
| Title |
Transcriptional response to aneuploidy in mouse epidermis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of the transcriptional response to aneuploidy in mouse epidermis. In this study we measured the transcriptional response to aneuploidy by aboragting the spindle checkpoint in mouse epidermis. We found that, whereas spindle checkpoint inactivation in the epidermis is tolerated, but results in metabolic deranged cells, SAC abrogation kills bulge stem cells
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| Overall design |
Mad2; K14-Cre mice were sacrificed at indicated timepoints and epidermis was separated from dermis using overnight trypsin. RNA was isolated and expression patterns were compared between K14-Cre; Mad2f/f and Cfre negative animals for all timepoints.
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| |
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| Contributor(s) |
Foijer F |
| Citation(s) |
23382243 |
| Submission date |
Dec 03, 2012 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Floris Foijer |
| E-mail(s) |
f.foijer@umcg.nl
|
| Organization name |
University Medical Center Groningen
|
| Department |
European Institute for the Biology of Ageing
|
| Lab |
Foijer lab
|
| Street address |
Antonius Deusinglaan 1
|
| City |
Groningen |
| ZIP/Postal code |
9713AV |
| Country |
Netherlands |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (24)
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| Relations |
| BioProject |
PRJNA182752 |
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