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Series GSE42789 Query DataSets for GSE42789
Status Public on Apr 01, 2013
Title Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: Comparison with immune activation
Organism Mus musculus
Experiment type Expression profiling by array
Summary We investigated the molecular mechanisms of chronic alcohol consumption or lipopolysaccharide insult by gene expression profiling in prefrontal cortex and liver of C57BL/6J mice.
We identified similar patterns of transcriptional changes in brain and liver among three different alcohol consumption tests and lipopolysaccharide injection.
We also demonstrated distinct genomic consequences of different types of alcohol consumption.
 
Overall design The microarray experiment was performed to compare gene expression changes induced by three separate paradigms of alcohol consumption and immune activation by lipopolysaccharide injection.
The three tests of alcohol consumption were the continuous chronic two bottle choice (Chronic), two bottle choice available every other day (Chronic Intermittent) and limited access to one bottle of ethanol (Drinking in the Dark).
All alcohol studies utilized 20% ethanol and each treatment group had it's own control group which received only water.
The immune activation test consisted of 2 lipopolysaccharide injections (1 mg/kg i.p.) spaced one week apart, with animals being sacrificed one week after the last injection. Control animals received saline injections.
All studies used female, adult mice.
 
Contributor(s) Osterndorff-Kahanek E, Ponomarev I, Blednov YA, Harris RA
Citation(s) 23555817
Submission date Dec 06, 2012
Last update date Jun 14, 2018
Contact name Elizabeth Osterndorff-Kahanek
Organization name University of Texas at Austin
Street address 2500 Speedway
City Austin
State/province TX
ZIP/Postal code 78712
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (159)
GSM1049927 PFC_Chronic-control_1
GSM1049928 PFC_Chronic-control_2
GSM1049929 PFC_Chronic-control_3
Relations
BioProject PRJNA183349

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE42789_RAW.tar 3.1 Mb (http)(custom) TAR
GSE42789_non-norm_CI_Liver.txt.gz 3.1 Mb (ftp)(http) TXT
GSE42789_non-norm_CI_PFC.txt.gz 3.1 Mb (ftp)(http) TXT
GSE42789_non-norm_Chronic_Liver.txt.gz 3.1 Mb (ftp)(http) TXT
GSE42789_non-norm_Chronic_PFC.txt.gz 2.9 Mb (ftp)(http) TXT
GSE42789_non-norm_DID_Liver.txt.gz 3.2 Mb (ftp)(http) TXT
GSE42789_non-norm_DID_PFC.txt.gz 3.1 Mb (ftp)(http) TXT
GSE42789_non-norm_LPS_Liver.txt.gz 3.2 Mb (ftp)(http) TXT
GSE42789_non-norm_LPS_PFC.txt.gz 3.1 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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