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| Status |
Public on Apr 29, 2013 |
| Title |
Ldb1-nucleated transcription complexes function as primary mediators of erythroid gene activation |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We used ChIP-Seq to map Ldb1, Scl and Gata1 binding sites in mouse total bone marrow cells. Together with functional studies comparing gene expression in Murine Erythroleukemia (MEL) cells expressing Ldb1 shRNA or control shRNA and bioinformatics analysis, we systematically determined the transcriptional program controlled by Ldb1 complexes in erythropoiesis.
This represents the ChIP-Seq component of the study only
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| |
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| Overall design |
To evaluate the role of Ldb1complexes in erythroid gene activation
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| |
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| Contributor(s) |
Li L, Freudenberg JM, Cui K, Dale R, Song S, Dean A, Zhao K, Jothi R, Love PE |
| Citation(s) |
23610375 |
| Submission date |
Dec 11, 2012 |
| Last update date |
May 15, 2019 |
| Contact name |
Raja Jothi |
| E-mail(s) |
jothi@mail.nih.gov
|
| Organization name |
National Institutes of Health
|
| Department |
National Institute of Environmental Health Sciences
|
| Lab |
Systems Biology
|
| Street address |
111 TW Alexander Drive; A314
|
| City |
RTP |
| State/province |
NC |
| ZIP/Postal code |
27709 |
| Country |
USA |
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| Platforms (1) |
| GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA183626 |
| SRA |
SRP017505 |
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