|
| Status |
Public on Feb 11, 2013 |
| Title |
TCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h.
|
| |
|
| Overall design |
Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose NY-ESO-1 multimer
|
| |
|
| Contributor(s) |
Rufer N, Hebeisen M, Baitsch L |
| Citation(s) |
23391724 |
| Submission date |
Dec 14, 2012 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Lukas Baitsch |
| E-mail(s) |
lukas_baitsch@dfci.harvard.edu
|
| Organization name |
Dana Farber Cancer Institute
|
| Department |
Cancer Biology
|
| Lab |
Jean Zhao
|
| Street address |
450 Brookline Avenue
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA183876 |
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