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Series GSE43034 Query DataSets for GSE43034
Status Public on Sep 05, 2013
Title Canonical Nlrp3 inflammasome activation links systemic age-related inflammation with functional decline
Organism Mus musculus
Experiment type Expression profiling by array
Summary This experiment was performed to analyze the contribution of NLRP3 inflammasome activation to age-related changes in hippocampal RNA. The hypothesis was that decreased inflammasome activation would reduce hippocampal inflammation.
Results indicate that inflammasome knockout animals are protected from age-related changes in hippocampal gene expression
 
Overall design Gene expression profiles of young (1 month) and old (21-23 month) wild type, CIAS -/- and ASC -/- mouse hippocampal tissue were compared. Total mRNA was extracted using Trizol.
 
Contributor(s) Youm Y, Dixit VD, Grant R, Albarado D, Ravussin A, Pistell P, Newman S, Laque A, Munzberg H, Ingram DK, Salbaum JM
Citation(s) 24093676
Submission date Dec 19, 2012
Last update date Jun 14, 2018
Contact name Ryan Grant
E-mail(s) ryan.grant@pbrc.edu
Phone 225-763-2763
Fax 225-763-0261
Organization name Pennington Biomedical Research Center
Lab Immunobiology
Street address 6400 Perkins Rd
City Baton Rouge
State/province LA
ZIP/Postal code 70808
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (32)
GSM1055342 Hippocampus, Wild type, young (1 month)-1
GSM1055343 Hippocampus, Wild type, young (1 month)-2
GSM1055344 Hippocampus, Wild type, young (1 month)-3
Relations
BioProject PRJNA184139

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43034_RAW.tar 3.1 Mb (http)(custom) TAR
GSE43034_non-normalized.txt.gz 4.9 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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