|
| Status |
Public on Apr 03, 2013 |
| Title |
Gene expression profile changes in PKC-inhibitor-pretreated HT1080 cells cells after TLR3 stimulation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
TLR3 stimulation by extracellular dsRNA (e.g. polyIC) induces expression of numerous genes. The inhibition of PKC by Go6976 prior to TLR3 stimulation leads to an ablation of expression of IRF-3-dependent genes.
|
| |
|
| Overall design |
Total RNA extracted from HT1080 cells with or without 1 h pretreatment with 5 uM Go6976, after 6 h of treatment with dsRNA (polyIC), compared to untreated controls
|
| |
|
| Contributor(s) |
Sen GC |
| Citation(s) |
23532979 |
| Submission date |
Dec 31, 2012 |
| Last update date |
Mar 20, 2017 |
| Contact name |
Ganes C. Sen |
| E-mail(s) |
seng@ccf.org
|
| Organization name |
Cleveland Clinic
|
| Street address |
9500 Euclid Avenue NE-20
|
| City |
Cleveland |
| ZIP/Postal code |
44195 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
|
| Samples (4)
|
| GSM1058794 |
PKC_inhibitor-treated_HT1080_dsRNA-treated_rep1 |
|
| Relations |
| BioProject |
PRJNA184996 |
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