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Series GSE43261 Query DataSets for GSE43261
Status Public on Dec 31, 2013
Title Fluoxetine resistance in mice is associated with attenuated progression of a stereotyped dentate gyrus gene expression program
Organism Mus musculus
Experiment type Expression profiling by array
Summary Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common treatment for major depression. However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems relate to treatment responses may be critical for understanding antidepressant resistance. Transcriptome profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to utilize this information to determine mechanisms underlying antidepressant treatment responses. However, the best way to relate this immense amount of information to treatment resistance remains unclear. We take a novel approach to this question by examining dentate gyrus transcriptomes from the perspective of a stereotyped fluoxetine-induced gene expression program. Expression programs usually represent stereotyped changes in expression levels that occur as cells transition phenotypes. Fluoxetine will shift transcriptomes so they lie somewhere between a baseline state and a full-response at the end of the program. The position along this fluoxetine-induced gene expression program (program status) was measured using principal components analysis (PCA). The same expression program was initiated in treatment-responsive and resistant mice but treatment response was associated with further progression along the fluoxetine-induced gene expression program. The study of treatment-related differences in gene expression program status represents a novel way to conceptualize differences in treatment responses at a transcriptome level. Understanding how antidepressant-induced gene expression program progression is modulated represents an important area for future research and could guide efforts to develop novel augmentation strategies for antidepressant treatment resistant individuals.
Overall design 38 samples, 2 dentate regions (dorsal/ventral), 3 groups (control, antidepressant resistant (4 mice), antidepressant responsive (7 mice), untreated (8 mice).
Citation(s) 24465494
Submission date Jan 03, 2013
Last update date Feb 11, 2019
Contact name mark alter
Organization name University of Pennsylvania
Department Center for Neurobiology and Behvior
Street address 125 S. 31st Street
City Philadelphia
State/province PA
ZIP/Postal code 19003
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (38)
GSM1059561 Dorsal Dentate Control #1
GSM1059562 Dorsal Dentate Control #2
GSM1059563 Dorsal Dentate Control #3
BioProject PRJNA185171

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Supplementary file Size Download File type/resource
GSE43261_RAW.tar 135.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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