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Series GSE43994 Query DataSets for GSE43994
Status Public on Jul 09, 2013
Title Identification of genes involved in SHH subgroup medulloblastoma using murine whole-body Sleeping Beauty insertional mutagenesis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Ptch+/- mice, which are predisposed to SHH subgroup medulloblastoma, were mutagenised using the Sleeping Beauty transposon to identify genes which increase the frequency of medulloblastoma formation. Gene expression in tumours was assessed both to investigate their relationship to human subgroup tumours, and to identify genes where expression was altered by mutagenesis.
Overall design Total RNA isolated from tumours induced by SB mutagenesis were compared to normal cerebellum, tumours induced witout SB mutagenesis, and tumours from a distinct model of disease (GTML).
Contributor(s) Jackson MS, Clifford SC, Williamson D, Chesler L, AlAfghani H
Citation(s) 24252690
Submission date Feb 01, 2013
Last update date Jun 14, 2018
Contact name Michael Stewart Jackson
Phone +44 191 241 8677
Organization name Newcastle University
Department Institute of Genetic Medicine
Street address Central Parkway
City Newcastle upon Tyne
ZIP/Postal code NE1 3BZ
Country United Kingdom
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (48)
GSM1076164 MB2-349
GSM1076165 MB3-754
GSM1076166 MB4-730
BioProject PRJNA188311

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43994_RAW.tar 3.1 Mb (http)(custom) TAR
GSE43994_non-normalized.txt.gz 9.1 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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