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| Status |
Public on Feb 05, 2013 |
| Title |
Genome-wide analysis of gene expression profile of Xenograft Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with Control (Ad-VP16) or LXRa (VP16hLXRa) Adenovirus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Changes in gene expression profile of Xenograft Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with Control (Ad-VP16) or LXRa (VP16hLXRa) Adenovirus. The hypothesis tested in the present study was that LXRa overexpression influence cancer growth modulating lipid metabolism in cancer cells. Results provide the information that LXRa induces genes encoding proteins able to regulate cholesterol efflux thus reducing tumor growth.
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| Overall design |
Total RNA obtained from Xenograft Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with LXRa (VP16hLXRa) Adenovirus was compared to total RNA extracted from Xenografted Tumors (HT29 cells) grown in Nu/Nu Athymic Female Mice infected with Control (Ad-VP16) Adenovirus.
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| Contributor(s) |
Bovenga F, Andria D |
| Citation(s) |
23419360 |
| Submission date |
Feb 05, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Antonio Moschetta |
| Organization name |
University of Bari & Consorzio Mario Negri Sud
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| Street address |
Via Nazionale 8A
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| City |
Santa Maria Imbaro |
| ZIP/Postal code |
66030 |
| Country |
Italy |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE44073 |
Liver X Receptors play an antitumoral role in the intestine |
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| Relations |
| BioProject |
PRJNA188558 |
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