|
| Status |
Public on Mar 18, 2014 |
| Title |
Hedgehog pathway inhibition in chondrosarcoma using the Smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Mice bearing primary human chondrosarcoma xenografts were treated with IPI 926, and mRNA levels of known Hh pathway genes and endpoint tumor volumes were measured.
Gene expression profiling of IPI-926 treated tumors was conducted to identify potential novel Hh target genes.
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| |
|
| Overall design |
4 Control treated and 4 IPI-926 treated NSG Mice. Primary tumor was obtained from a single chondrosarcoma patient.
|
| |
|
| Contributor(s) |
Veronica C, Jay W |
| Citation(s) |
24634412 |
| Submission date |
Feb 22, 2013 |
| Last update date |
Jan 23, 2019 |
| Contact name |
John Keilty |
| E-mail(s) |
john.keilty@infi.com
|
| Phone |
6174531160
|
| Organization name |
Infinity Pharmaceuticals
|
| Department |
Informatics
|
| Street address |
780 Memorial Drive
|
| City |
Cambridge |
| State/province |
Massachusetts |
| ZIP/Postal code |
02139 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA190094 |
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