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Series GSE44623 Query DataSets for GSE44623
Status Public on Feb 26, 2013
Title Transcriptional responses of the zebrafish (Danio rerio) brain to acute sodium selenite supplementation.
Organism Danio rerio
Experiment type Expression profiling by array
Summary The possible benefits of selenium (Se) supplementation are currently under investigation for prevention of certain cancers and treatment of neurological disorders. Little is known concerning the response of the brain to increased dietary Se under conditions of Se sufficiency, despite the majority of Se supplementation trials occurring in healthy subjects considered Se sufficient. We evaluated the transcriptional response of the zebrafish (Danio rerio) brain to supplementation with nutritionally relevant levels of dietary Se (sodium selenite) during conditions of assumed Se sufficiency.
We used a microarray approach to analyze the global gene expression response of the brain to dietary Se supplementation for 14 days.
Overall design The experiment used Affymetrix microarrays to compare whole brain RNA from 8 adult zebrafish (Danio rerio) fed a diet with control selenium levels (1.4ppmSe) and 8 fed a diet supplemented with sodium selenite (5.6ppmSe) for 14 days, and with an equal sex ratio within each diet.
Contributor(s) Benner MJ, Robison BD, Settles ML, Murdoch GK, Hardy RW
Citation(s) 23737534
Submission date Feb 25, 2013
Last update date Jan 25, 2018
Contact name Maia J Benner
Organization name University of Idaho
Department Biological Sciences
Lab Barrie Robison
Street address 875 Perimeter Drive
City Moscow
State/province Idaho
ZIP/Postal code 83844-3051
Country USA
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (15)
GSM1088000 female brain 102, control
GSM1088001 female brain 124, control
GSM1088002 famale brain 133, control
BioProject PRJNA190674

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Supplementary file Size Download File type/resource
GSE44623_RAW.tar 34.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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