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| Status |
Public on Feb 26, 2013 |
| Title |
Transcriptional responses of the zebrafish (Danio rerio) brain to acute sodium selenite supplementation. |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by array
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| Summary |
The possible benefits of selenium (Se) supplementation are currently under investigation for prevention of certain cancers and treatment of neurological disorders. Little is known concerning the response of the brain to increased dietary Se under conditions of Se sufficiency, despite the majority of Se supplementation trials occurring in healthy subjects considered Se sufficient. We evaluated the transcriptional response of the zebrafish (Danio rerio) brain to supplementation with nutritionally relevant levels of dietary Se (sodium selenite) during conditions of assumed Se sufficiency.
We used a microarray approach to analyze the global gene expression response of the brain to dietary Se supplementation for 14 days.
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| Overall design |
The experiment used Affymetrix microarrays to compare whole brain RNA from 8 adult zebrafish (Danio rerio) fed a diet with control selenium levels (1.4ppmSe) and 8 fed a diet supplemented with sodium selenite (5.6ppmSe) for 14 days, and with an equal sex ratio within each diet.
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| Contributor(s) |
Benner MJ, Robison BD, Settles ML, Murdoch GK, Hardy RW |
| Citation(s) |
23737534 |
| Submission date |
Feb 25, 2013 |
| Last update date |
Jan 25, 2018 |
| Contact name |
Maia J Benner |
| E-mail(s) |
maiabenner@gmail.com
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| Organization name |
University of Idaho
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| Department |
Biological Sciences
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| Lab |
Barrie Robison
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| Street address |
875 Perimeter Drive
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| City |
Moscow |
| State/province |
Idaho |
| ZIP/Postal code |
83844-3051 |
| Country |
USA |
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| Platforms (1) |
| GPL1319 |
[Zebrafish] Affymetrix Zebrafish Genome Array |
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| Samples (15)
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| GSM1088003 |
female brain 120, selenium |
| GSM1088004 |
female brain 122, selenium |
| GSM1088005 |
female brain 129, selenium |
| GSM1088006 |
female brain 136, selenium |
| GSM1088007 |
male brain 99, control |
| GSM1088008 |
male brain 108, control |
| GSM1088009 |
male brain 111, control |
| GSM1088010 |
male brain 121, control |
| GSM1088011 |
male brain 98, selenium |
| GSM1088012 |
male brain 101, selenium |
| GSM1088013 |
male brain 105, selenium |
| GSM1088014 |
male brain 109, selenium |
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| Relations |
| BioProject |
PRJNA190674 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE44623_RAW.tar |
34.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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