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| Status |
Public on Mar 29, 2013 |
| Title |
microRNA-190-mediated transcriptional changes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Previously, we showed that miRNA-190 (miR-190) is among the most upregulated miRNAs in all dormant tumors analyzed. Up-regulation of miR-190 led to prolonged tumor dormancy in otherwise fast-growing glioblastomas and osteosarcomas. In this study, we investigated transcriptional changes induced by miR-190 expression in cancer cells and show similar patterns of miR-190-mediated transcriptional reprogramming in both glioblastoma and osteosarcoma cells. The data suggests that miR-190-mediated effects rely on an extensive network of molecular changes in tumor cells and that miR-190 affects several transcriptional factors, tumor suppressor genes and interferon response pathways.
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| Overall design |
For each cancer cell type, gene expression patterns in control cells that express GFP-only were compared to cells over-expressing microRNA-190.
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| Contributor(s) |
Briggs C, Almog N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 27, 2013 |
| Last update date |
Aug 13, 2018 |
| Contact name |
christine elaine briggs |
| E-mail(s) |
cebriggs7135@gmail.com
|
| Phone |
617 905-9301
|
| Organization name |
christine briggs
|
| Department |
Center for Cancer Systems Biology
|
| Lab |
Hlatky
|
| Street address |
736 Cambridge Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02135 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA195378 |
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