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| Status |
Public on Apr 30, 2013 |
| Title |
Epstein-Barr virus maintains lymphomas via its miRNAs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Epstein‐Barr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocytes, not only directing these cells during latency to proliferate and thereby expand the pool of infected cells, but also to survive and thereby persist for the lifetime of the infected individual. Although these activities ensure the virus is successful, they also make the virus oncogenic, particularly when infected people are immunosuppressed. Here we show, strikingly, that one set of EBV’s miRNAs both sustain BL (Burkitt’s lymphoma) cells in the absence of other viral oncogenes and promote the transformation of primary B lymphocytes. Burkitt’s Lymphoma cells were engineered to lose EBV and found to die by apoptosis and could be rescued by constitutively expressing viral miRNAs in them. Two of these EBV miRNAs were found to target Caspase 3 to inhibit apoptosis at physiological concentrations.
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| Overall design |
Examination of RISC associated transcripts under 4 conditions in Sav S1-1 cells
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| Contributor(s) |
Vereide DT, Seto E, Chiu Y, Hayes M, Tagawa T, Grundhoff A, Hammerschmidt W, Sugden B |
| Citation(s) |
23503461 |
| Submission date |
Mar 01, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Bill Sugden |
| E-mail(s) |
sugden@oncology.wisc.edu
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| Organization name |
University of Wisconsin-Madison
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| Street address |
1111 Highland Ave
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| City |
Madison |
| State/province |
WI |
| ZIP/Postal code |
53705 |
| Country |
USA |
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| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA192693 |
| SRA |
SRP019222 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE44769_processed_data_rpkm.xls.gz |
5.6 Mb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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