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| Status |
Public on Nov 21, 2006 |
| Title |
Expression data of small airway epithelium from phenotypically normal smokers and non-smokers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Modification of Gene Expression of the Small Airway Epithelium in Response to Cigarette Smoking
The earliest morphologic evidence of changes in the airways associated with chronic cigarette smoking is in the small airways. To help understand how smoking modifies small airway structure and function, we developed a strategy using fiberoptic bronchoscopy and brushing to sample the human small airway (10th-12th order) bronchial epithelium to assess gene expression (HG-133 Plus 2.0 array) in phenotypically normal smokers (n=10, 33 ± 7 pack-yr) compared to matched non-smokers (n=12). Even though the smokers were phenotypically normal, analysis of the small airway epithelium of the smokers compared to the non-smokers demonstrated up- and -down-regulation of genes in multiple categories relevant to the pathogenesis of chronic obstructive lung disease (COPD), including genes coding for cytokines/innate immunity, apoptosis, mucin, response to oxidants and xenobiotics, and general cellular processes. In the context that COPD starts in the small airways, these gene expression changes in the small airway epithelium in phenotypically normal smokers are candidates for the development of therapeutic strategies to prevent the onset of COPD.
Keywords: smokers vs non-smokers
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| Overall design |
comparison of gene expression in airway epithelial cells of the small airways of healthy smokers vs healthy non-smokers
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| Contributor(s) |
Heguy A, Harvey B, Leopold P, Carolan B, Ferris B, Crystal R |
| Citation(s) |
17115125, 19106307 |
| Submission date |
Mar 20, 2006 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Yael Strulovici-Barel |
| E-mail(s) |
yas2003@med.cornell.edu
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| Organization name |
Weill Cornell Medical College
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| Department |
Department of Genetic Medicine
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| Lab |
Crystal
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| Street address |
1300 York Avenue
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (22)
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| GSM101095 |
small airways, non-smoker 001, RMA and MAS |
| GSM101096 |
small airways, non-smoker 004, RMA and MAS |
| GSM101097 |
small airways, non-smoker 002, RMA and MAS |
| GSM101098 |
small airways, non-smoker 003, RMA and MAS |
| GSM101099 |
small airways, non-smoker 013, RMA and MAS |
| GSM101100 |
small airways, non-smoker 006, RMA and MAS |
| GSM101101 |
small airways, non-smoker 021, RMA and MAS |
| GSM101102 |
small airways, non-smoker 019, RMA and MAS |
| GSM101103 |
small airways, non-smoker 014, RMA and MAS |
| GSM101104 |
small airways, non-smoker 008, RMA and MAS |
| GSM101105 |
small airways, non-smoker 015, RMA and MAS |
| GSM101106 |
small airways, non-smoker 005, RMA and MAS |
| GSM101107 |
small airways, smoker 002, RMA and MAS |
| GSM101108 |
small airways, smoker 003, RMA and MAS |
| GSM101109 |
small airways, smoker 027, RMA and MAS |
| GSM101110 |
small airways, smoker 033, RMA and MAS |
| GSM101111 |
small airways, smoker 001, RMA and MAS |
| GSM101112 |
small airways, smoker 023, RMA and MAS |
| GSM101113 |
small airways, smoker 048, RMA and MAS |
| GSM101114 |
small airways, smoker 041, RMA and MAS |
| GSM101115 |
small airways, smoker 044, RMA and MAS |
| GSM101116 |
small airways, smoker 049, RMA and MAS |
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| Relations |
| BioProject |
PRJNA94381 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE4498_RAW.tar |
464.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data provided as supplementary file |
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