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| Status |
Public on Mar 12, 2013 |
| Title |
MicroRNA Expression of Mouse Cochleae during Aging |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To identify which miRNAs are involved in the onset and progression of age-related hearing loss in the mammalian cochlea
We used miRNA microarrays to screen miRNAs which exhibit the differential expression in the expressing levels during aging of the cochlea
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| Overall design |
The organ of Corti (OC), one of the major pathological sites of presbycusis in cochlea, was collected separately at 3 timepoints during the life span. Two strains were selected: C57BL/6J and CBA/J. The selected time points were: Postnatal 21 days (P21), 3 month (3m) and 9 month (9m) for C57 mice, and P21, 9m, 16m for CBA mice.
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| Contributor(s) |
Zhang Q, Liu HZ, Walsh E, McGee J, Soukup G, He DZ |
| Citation(s) |
23646144 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 DC004696 |
Biophysics and Development of Cochlear Hair Cells: BIOPHYSICS AND DEVELOPMENT OF COCHLEAR OUTER HAIR CELLS: Biophysics and Development of Cochlear Hair Cells: BIOPHYSICS AND DEVELOPMENT OF COCHLEAR OUTER HAIR CELLS: BIOPHYSICS AND DEVELOPMENT OF COCHLEAR OUTER HAIR CELLS: Biophysics and Development of Cochlear Hair Cells: Biophysics and Development of Cochlear Hair Cells: Biophysics and Development of Cochlear Hair Cells: Biophysics and Development of Cochlear Hair Cells: Biophysics and Development of Cochlear Hair Cells: Biophysics and Development of Cochlear Hair Cells: Biophysics and Development of Cochlear Hair Cells |
CREIGHTON UNIVERSITY |
David Z.Z. He |
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| Submission date |
Mar 11, 2013 |
| Last update date |
Sep 11, 2017 |
| Contact name |
David Z.Z. He |
| E-mail(s) |
hed@creighton.edu
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| Phone |
14022801409
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| Organization name |
Creighton University
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| Department |
Department of Biomedical Sciences
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| Street address |
2500 California Plaza
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| City |
Omaha |
| State/province |
Nebraska |
| ZIP/Postal code |
68178 |
| Country |
USA |
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| Platforms (1) |
| GPL8786 |
[miRNA-1] Affymetrix Multispecies miRNA-1 Array |
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| Samples (18)
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| GSM1095937 |
OC tissue of CBA at P21, biological rep1 |
| GSM1095938 |
OC tissue of CBA at P21, biological rep2 |
| GSM1095939 |
OC tissue of CBA at P21, biological rep3 |
| GSM1095940 |
OC tissue of CBA at 9m, biological rep1 |
| GSM1095941 |
OC tissue of CBA at 9m, biological rep2 |
| GSM1095942 |
OC tissue of CBA at 9m, biological rep3 |
| GSM1095943 |
OC tissue of CBA at 16m, biological rep1 |
| GSM1095944 |
OC tissue of CBA at 16m, biological rep2 |
| GSM1095945 |
OC tissue of CBA at 16m, biological rep3 |
| GSM1095946 |
OC tissue of C57 at P21, biological rep1 |
| GSM1095947 |
OC tissue of C57 at P21, biological rep2 |
| GSM1095948 |
OC tissue of C57 at P21, biological rep3 |
| GSM1095949 |
OC tissue of C57 at 3m, biological rep1 |
| GSM1095950 |
OC tissue of C57 at 3m, biological rep2 |
| GSM1095951 |
OC tissue of C57 at 3m, biological rep3 |
| GSM1095952 |
OC tissue of C57 at 9m, biological rep1 |
| GSM1095953 |
OC tissue of C57 at 9m, biological rep2 |
| GSM1095954 |
OC tissue of C57 at 9m, biological rep3 |
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| Relations |
| BioProject |
PRJNA192856 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE45026_RAW.tar |
3.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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