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| Status |
Public on Mar 31, 2014 |
| Title |
Increased Neanderthal ancestry in genomic regions associated with lipid catabolism in contemporary Europeans |
| Organisms |
Pan troglodytes; Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
While Neanderthals are extinct, fragments of their genome still persist in the genomes of contemporary humans. Here, we show that such Neanderthal-like sequences are not distributed randomly in contemporary human genomes. Specifically, while genome-wide frequency of Neanderthal-like sites is close to 6% in all out-of-Africa populations, genes involved in lipid catabolism contain large excess Neanderthal-like sequences in Europeans (24.3%), but not in Asians (12.4%). While lipid catabolism cannot be assayed in Neanderthals, we took advantage of genetic divergence between human populations, chimpanzees and Neanderthals to predict metabolic divergence expected from the observed excess of Neanderthal gene flow into Europeans. We confirmed predicted changes in lipid catabolism using hydrophobic metabolome measurements in the brain tissue and further linked these metabolic changes to gene expression divergence.
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| Overall design |
14 human and 6 chimpanzee samples were sequenced.
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| Contributor(s) |
Khaitovich P |
| Citation(s) |
24690587 |
| Submission date |
Mar 18, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Liu He |
| E-mail(s) |
heliu@picb.ac.cn
|
| Organization name |
PICB
|
| Street address |
320 Yue Yang Road
|
| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (2) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL16809 |
Illumina HiSeq 2000 (Pan troglodytes) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA193342 |
| SRA |
SRP019762 |
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