|
| Status |
Public on Mar 31, 2014 |
| Title |
Transcriptome analysis in host defense during high multiplicity mycobacterial infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
This experiment is to compare the transcription patterns of mouse macrophages (J774A.1) infected with BCG, H37Ra and M. smegmatis under high multiplicity of infection (MOI). Through the global transcriptome profiling study, we define a pathogen specific host gene expression pattern and indicate that SRC likely plays a central role in regulating multiple unique signaling pathways activated by MTB infection. Mycobacterium tuberculosis (MTB) infects an estimated one-third of the global population and is one of the main causes of mortality due to an infectious agent.
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| |
|
| Overall design |
high multiplicity mycobacterial infection of BCG, H37Ra and M.semg
|
| |
|
| Contributor(s) |
Zhang J |
| Citation(s) |
23824656 |
| Submission date |
Apr 01, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jay Zhang |
| Organization name |
Griffith Health Institute
|
| Street address |
Gold Coast Campus
|
| City |
San Diego |
| State/province |
Southport |
| ZIP/Postal code |
QLD 4222 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA195591 |
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