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Series GSE46026 Query DataSets for GSE46026
Status Public on Apr 01, 2014
Title Acute and long-term responses to radiation in zebrafish
Organism Danio rerio
Experiment type Expression profiling by array
Summary A set of changes is identified in the transcription profile associated with the long-term, but not the acute, response to radiation exposure. The study was performed in vivo using zebrafish.
To study the long-term response, 24 hour post-fertilization embryos were exposed to 0.1 Gy (low dose) or 1.0 Gy (moderate dose) of whole-body gamma radiation and allowed to develop for 16 weeks. Liver mRNA profiles were then analyzed using the Affymetrix microarray platform, with validation by quantitative PCR. To be able to compare this to the acute response, 16-week old adults were exposed at the same doses and analyzed after 4 hours.
 
Overall design We used 5 treatment groups: A=non-irradiated control, allowed to develop for 16 weeks; B=low-dose (0.1 Gy) irradiated, allowed to develop for 16 weeks; C=high-dose (1.0 Gy) irradiate, allowed to develop for 16 weeks; D=16 week old adults irradiated at low dose (0.1 Gy); E=16 week old adults irradiate at high dose (1.0 Gy)
 
Contributor(s) Podolsky R, Dynan W
Citation(s) 23936019
Submission date Apr 12, 2013
Last update date Jan 25, 2018
Contact name Robert Podolsky
E-mail(s) rpodolsky@gru.edu
Phone 7067216335
Organization name Georgia Regents University
Street address 1120 15th St, CA-4094
City Augusta
State/province GA
ZIP/Postal code 30912
Country USA
 
Platforms (1)
GPL1319 [Zebrafish] Affymetrix Zebrafish Genome Array
Samples (15)
GSM1122072 Non-irradiate control, biological replicate 1
GSM1122073 Adult irradiated, low dose, replicate 1
GSM1122074 Adult irradiated, low dose, replicate 2
Relations
BioProject PRJNA196919

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46026_RAW.tar 27.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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