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| Status |
Public on Apr 30, 2013 |
| Title |
[E-MEXP-3786] IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcription profiling by array of mouse male retinas to investigate IGF-I-induced chronic gliosis and retinal stress
IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impaired electroretinographic responses at 6-7 months of age that worsen with age. This retinal neuronal dysfunction was correlated with the loss of rod photoreceptors, bipolar, ganglion and amacrines cells. Neuronal alterations were preceded by the overexpression of retinal stress markers, acute phase proteins and gliosis-related genes. IGF-I overexpression leads to chronic gliosis and microgliosis in TgIGF-I retinas, with mild oxidative stress, impaired recycling of glutamate and defective potassium buffering. These impaired supportive functions can contribute to neurodegeneration in TgIGF-I retinas, together with the increased production of pro-inflammatory cytokines, potential mediators of neuronal death.
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| Overall design |
3 transgenic and 3 wild type biological replicates examined.
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| Contributor(s) |
Ribera A |
| Citation(s) |
23620587 |
| Submission date |
Apr 21, 2013 |
| Last update date |
May 04, 2018 |
| Contact name |
Miquel Garcia |
| E-mail(s) |
miquel.garcia@uab.es
|
| Phone |
935814177
|
| Organization name |
UAB
|
| Street address |
Campus UAB Edifici H
|
| City |
Bellaterra |
| State/province |
-- Please Select (only U.S. / Can / Aus) |
| ZIP/Postal code |
08196 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (6)
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| Relations |
| ArrayExpress |
E-MEXP-3786 |
| BioProject |
PRJNA198461 |
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