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| Status |
Public on Oct 09, 2013 |
| Title |
A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Tmprss6 is the master inhibitor of hepcidin and its inactivation causes iron refractory iron deficiency anemia both in human and in mice. Mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficienct-high hepcidin Tmprss6 null mice. We investigated the transcriptional response associated with chronic hepcidin overexpression by comparing whole genome transcription profiling of the liver of Tmprss6 KO mice and IDA animals, irrespective of iron deficiency.
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| Overall design |
Total liver RNA obtained from Tmprss6 KO mice were compared to wild type (iron deficient) animals, under basal conditions and after LPS challenge
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| Contributor(s) |
Riba M, Rausa M, Sorosina M, Cittaro D, Garcia Manteiga JM, Martinelli Boneschi F, Nai A, Pagani A, Stupka E, Camaschella C, Silvestri L |
| Citation(s) |
23922777 |
| Submission date |
Apr 22, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Michela Riba |
| E-mail(s) |
riba.michela@gmail.com
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| Organization name |
IRCCS, Ospdale San Raffaele
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| Department |
COSR, Center for Omics Sciences
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| Street address |
via Olgettina 60
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| City |
Milano |
| ZIP/Postal code |
20032 |
| Country |
Italy |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (12)
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| GSM1128154 |
iron deficient control littermates, saline injected 1 |
| GSM1128155 |
iron deficient control littermates, saline injected 2 |
| GSM1128156 |
iron deficient control littermates, saline injected 3 |
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| Relations |
| BioProject |
PRJNA198530 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE46287_RAW.tar |
15.8 Mb |
(http)(custom) |
TAR |
| GSE46287_non-normalized_data.txt.gz |
3.5 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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