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Series GSE46287 Query DataSets for GSE46287
Status Public on Oct 09, 2013
Title A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Tmprss6 is the master inhibitor of hepcidin and its inactivation causes iron refractory iron deficiency anemia both in human and in mice. Mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficienct-high hepcidin Tmprss6 null mice. We investigated the transcriptional response associated with chronic hepcidin overexpression by comparing whole genome transcription profiling of the liver of Tmprss6 KO mice and IDA animals, irrespective of iron deficiency.
 
Overall design Total liver RNA obtained from Tmprss6 KO mice were compared to wild type (iron deficient) animals, under basal conditions and after LPS challenge
 
Contributor(s) Riba M, Rausa M, Sorosina M, Cittaro D, Garcia Manteiga JM, Martinelli Boneschi F, Nai A, Pagani A, Stupka E, Camaschella C, Silvestri L
Citation(s) 23922777
Submission date Apr 22, 2013
Last update date Jan 16, 2019
Contact name Michela Riba
E-mail(s) riba.michela@gmail.com
Organization name San Raffaele Scientific Institute
Street address via Olgettina 60
City Milano
ZIP/Postal code 20032
Country Italy
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (12)
GSM1128154 iron deficient control littermates, saline injected 1
GSM1128155 iron deficient control littermates, saline injected 2
GSM1128156 iron deficient control littermates, saline injected 3
Relations
BioProject PRJNA198530

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46287_RAW.tar 15.8 Mb (http)(custom) TAR
GSE46287_non-normalized_data.txt.gz 3.5 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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