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Series GSE464 Query DataSets for GSE464
Status Public on Jul 16, 2003
Title CNS Regeneration
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or desease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulting in loss of neuronal function.

Hypothesis: Spinal cord injury (SCI) induces a cascade of molecular events including the activation of genes associated with transcription factors, inflammation, oxidative stress, ionic imbalance, apoptosis and neuroregeneration which suggests the existance of endogenous reparative attempts. However, not all mechanisms following SCI are well known.

Specific Aim: The goal of this project is to analyze the molecular events following spinal cord injury 1 cm above, below, and at the site of injury (T9), aiming at finding potential new targets to improve recovery and therapy.
Keywords: other
 
 
Contributor(s) Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI
Citation(s) 12666113
Submission date Jun 25, 2003
Last update date Oct 01, 2019
Contact name Eric P Hoffman
E-mail(s) ericphoffman@gmail.com
Organization name Binghamton University - SUNY
Department Pharmaceutical Sciences
Street address PO Box 6000
City Binghamton
State/province NY
ZIP/Postal code 13902
Country USA
 
Platforms (3)
GPL85 [RG_U34A] Affymetrix Rat Genome U34 Array
GPL86 [RG_U34B] Affymetrix Rat Genome U34 Array
GPL87 [RG_U34C] Affymetrix Rat Genome U34 Array
Samples (544)
GSM1136 CNS-SC_Inj24h-3A-s2
GSM1137 CNS-SC_Inj24h-4A-s2b
GSM1323 CNS-SpinalC-30mAdult-1A-s2
Relations
BioProject PRJNA85073

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE464_RAW.tar 1.1 Gb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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