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Series GSE46478 Query DataSets for GSE46478
Status Public on Oct 01, 2013
Title Transcriptional profile of WT, PRR and IFN-/- dendritic cells stimulated with poly IC in vivo
Organism Mus musculus
Experiment type Expression profiling by array
Summary Analysis of the specific transcriptional changes on DCs provided by direct pattern recogition receptor (PRR) or IFNAR signaling that are required for DC maturation after poly IC stimulation. Results provide important information about the intricate differentiation process of DC maturation and the importance of type I IFNs for DC immunogenicity.
 
Overall design WT/IFNA-/- or WT/PRR-/- mixed-chimera mice were injected with 50 ug Poly-IC i.p. in vivo 4 and 14 hr later, wild type and KO CD11chi CD3- DX5- B220- DCs were FACS sorted based on CD45.2 expression. Total RNA was isolated and expression profile was compared between unstimulated and activated WT and KO DCs.
 
Contributor(s) Longhi P
Citation(s) 24409099
Submission date Apr 29, 2013
Last update date Jun 14, 2018
Contact name Paula Longhi
E-mail(s) mlonghi@rockefeller.edu
Organization name The Rockefeller University
Street address 1230 York Av
City New York
ZIP/Postal code 10065
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (36)
GSM1130866 Unstimulated DC 1
GSM1130867 Unstimulated DC 2
GSM1130868 Unstimulated DC 3
Relations
BioProject PRJNA200593

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46478_RAW.tar 3.1 Mb (http)(custom) TAR
GSE46478_non-normalized.txt.gz 5.7 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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