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Series GSE46584 Query DataSets for GSE46584
Status Public on Jun 24, 2014
Title Expression data from sympathetic nervous system of KI Alk F1178L mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Neuroblastoma is an embryonal neoplasm that remains of dramatic prognosis in its aggressive forms. Activating mutations of the ALK tyrosine kinase receptor have been identified in sporadic and familial cases of this cancer. We generated knock-in mice carrying an F1178L Alk mutation corresponding to the ALK F1174L mutation observed in neuroblastoma patients
We used microarrays to detail the global programme of gene expression underlying the impact of ALK F1178L mutation on sympathetic nervous system ganglia
 
Overall design We selected sympathetic nervous system ganglia (superior cervical and stellate ganglia) for RNA extraction and hybridization on Affymetrix microarrays. We profiled a total number of 12 Po (4 Wt; 4 Hz; 4 Ho) and 5 P18 (3 Wt; 2 Hz)
 
Contributor(s) Janoueix-Lerosey I, Cazes A
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Submission date May 02, 2013
Last update date Jun 24, 2014
Contact name Alex Cazes
E-mail(s) alex.cazes@curie.fr
Organization name Institut Curie
Street address 26 rue d'Ulm
City paris
State/province Please select...
ZIP/Postal code 75005
Country France
 
Platforms (1)
GPL16225 [Mouse430_2_Mm_ENTREZG_14.1.0] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 14]
Samples (17)
GSM1132932 SNSganglia-F1178L-P0.1.Wt
GSM1132933 SNSganglia-F1178L-P0.2.Wt
GSM1132934 SNSganglia-F1178L-P0.3.Wt
Relations
BioProject PRJNA201042

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46584_RAW.tar 59.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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