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Status |
Public on Jun 24, 2014 |
Title |
Expression data from sympathetic nervous system of KI Alk F1178L mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Neuroblastoma is an embryonal neoplasm that remains of dramatic prognosis in its aggressive forms. Activating mutations of the ALK tyrosine kinase receptor have been identified in sporadic and familial cases of this cancer. We generated knock-in mice carrying an F1178L Alk mutation corresponding to the ALK F1174L mutation observed in neuroblastoma patients We used microarrays to detail the global programme of gene expression underlying the impact of ALK F1178L mutation on sympathetic nervous system ganglia
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Overall design |
We selected sympathetic nervous system ganglia (superior cervical and stellate ganglia) for RNA extraction and hybridization on Affymetrix microarrays. We profiled a total number of 12 Po (4 Wt; 4 Hz; 4 Ho) and 5 P18 (3 Wt; 2 Hz)
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Contributor(s) |
Janoueix-Lerosey I, Cazes A |
Citation missing |
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Submission date |
May 02, 2013 |
Last update date |
Jun 24, 2014 |
Contact name |
Alex Cazes |
E-mail(s) |
alex.cazes@curie.fr
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Organization name |
Institut Curie
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Street address |
26 rue d'Ulm
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City |
paris |
State/province |
Please select... |
ZIP/Postal code |
75005 |
Country |
France |
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Platforms (1) |
GPL16225 |
[Mouse430_2_Mm_ENTREZG_14.1.0] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 14] |
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Samples (17)
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Relations |
BioProject |
PRJNA201042 |