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Series GSE46646 Query DataSets for GSE46646
Status Public on Dec 13, 2013
Title IQGAP2 knockout model of hepatocellular carcinoma
Organism Mus musculus
Experiment type Expression profiling by array
Summary Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. Results provide insights into the potential role of IQGAP2 as a liver-specific tumor suppressor.
Overall design Transcript profiles of four groups of mouse livers (N = 3 in each group) were compared using Affymetrix GeneChip® Mouse Genome 430 2.0 Array. The groups included livers from 6- and 24-month-old wild-type (WT) mice and 6- and 24-month-old (KO) Iqgap2-/- mice.
Contributor(s) Gnatenko DV, Xu X, Zhu W, Schmidt VA
Citation(s) 23951254
Submission date May 05, 2013
Last update date Feb 11, 2019
Contact name Dmitri V GNATENKO
Phone 631-444-1264
Organization name Stony Brook University
Department Medicine
Street address T15/053 HSC SUNY
City Stony Brook
State/province NY
ZIP/Postal code 11794
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM1133576 Knockout mouse at 6 months, biological replicate 1
GSM1133577 Knockout mouse at 6 months, biological replicate 2
GSM1133578 Knockout mouse at 6 months, biological replicate 3
BioProject PRJNA201382

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Supplementary file Size Download File type/resource
GSE46646_RAW.tar 44.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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