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| Status |
Public on May 17, 2013 |
| Title |
gene expression profile of CBZ treated mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Carbamazepine (CBZ) is widely used in the treatment of neuropsychiatric disorders as an anticonvulsant. A recent report revealed that CBZ has an anti-fibrotic effect on the livers of α1-antitrypsin-deficient mice, raising the possibility of a hepatology-related therapeutic use for the drug.Given the fact that CBZ has complicated pharmacokinetic properties, to comprehensively understand the its mechanism of action, we performed microarray analysis of the mouse liver tissues 2 hours after CBZ administration.
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| Overall design |
The mice were orally administered 250 mg/kg of CBZ or DMSO and examined for the gene expression 2 hours later; 3 mice per group.
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| Contributor(s) |
Kawaguchi T, Kodama T |
| Citation missing |
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| Submission date |
May 08, 2013 |
| Last update date |
Jul 19, 2017 |
| Contact name |
Tsukasa Kawaguchi |
| Organization name |
Osaka University Graduate School of Medicine
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| Department |
Gastroenterology and Hepatology
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| Street address |
2-2 Yamada-oka, Suita
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| City |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA202202 |
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