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Series GSE46743 Query DataSets for GSE46743
Status Public on Sep 01, 2013
Title Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mech- anisms through which these factors interact to confer depression risk are poorly understood. One putative biological mechanism implicates variability in the ability of cortisol, released in response to stress, to trigger a cascade of adaptive genomic and non-genomic processes through glucocorticoid receptor (GR) activation. Here, we demonstrate that common genetic variants in long-range enhancer elements modulate the immediate transcriptional response to GR activation in human blood cells. These functional genetic variants increase risk for depression and co-heritable psychiatric disorders. Moreover, these risk variants are associated with inappropriate amygdala reactivity, a transdiagnostic psychiatric endophenotype and an important stress hormone response trigger. Network modeling and animal experiments suggest that these genetic dif- ferences in GR-induced transcriptional activation may mediate the risk for depression and other psy- chiatric disorders by altering a network of function- ally related stress-sensitive genes in blood and brain.
 
Overall design A Dexamethasone Suppression Test was performed in 160 male subjects. Baseline and stimulated (3 hours after 1.5 mg dexamethasone p.o.) whole blood samples were analyzed using Illumina Human HT-12 v3 arrays.
 
Contributor(s) Arloth J, Binder EB
Citation(s) 26050039
Submission date May 08, 2013
Last update date Aug 09, 2019
Contact name Janine Arloth
Organization name Max Planck Institute of Psychiatry
Street address Kraepelinstr. 2-10
City Munich
ZIP/Postal code 80804
Country Germany
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (320)
GSM1137699 baseline subject 1
GSM1137700 stimulated subject 1
GSM1137701 baseline subject 2
Relations
BioProject PRJNA202220

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46743_RAW.tar 6.2 Mb (http)(custom) TAR
GSE46743_non-normalized.txt.gz 96.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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