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Series GSE46750 Query DataSets for GSE46750
Status Public on May 20, 2013
Title Gene expression pattern of synovial cells from inflammatory and normal areas of osteoarthritis synovial membrane
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The aim of this study was to compare the gene expression pattern of synovial cells from inflammatory (I) or normal/reactive (N/R) areas of a synovial membrane harvested from the same osteoarthritis (OA) patient. This study is the first to identify different expression pattern between two areas of the synovial membrane in the same patient. These differences concern several key pathways involved in OA pathogenesis (inflammation, cartilage metabolism, Wnt signaling and angiogenesis). This analysis also provides interesting information regarding new potent intermediates as potentiel targets for the future therapeutic.
 
Overall design Synovial tissues were obtained from 12 knee OA patients at the time of total knee replacement. The inflammatory status of the synovial membrane was characterized according to macroscopic criteria and sorted as N/R and I. Biopsies were cultured separately for 7 days. Microarray gene expression profiling between N/R and I areas was performed.
 
Contributor(s) Henrotin Y, Lambert C
Citation(s) 24757147
Submission date May 08, 2013
Last update date Feb 03, 2020
Contact name Cecile LAMBERT
E-mail(s) cecile.lambert@ulg.ac.be
Phone +32 4 366 4383
Fax +32 4 366 4734
Organization name University of Liege
Lab Bone and cartilage research Unit
Street address avenue de l Hopital, 3
City Liege
ZIP/Postal code 4000
Country Belgium
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (24)
GSM1138130 synovial_membrane_normal/reactive_sample1
GSM1138131 synovial_membrane_normal/reactive_sample2
GSM1138132 synovial_membrane_normal/reactive_sample3
Relations
BioProject PRJNA202240

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46750_RAW.tar 26.2 Mb (http)(custom) TAR
GSE46750_non-normalized.txt.gz 6.9 Mb (ftp)(http) TXT
Processed data included within Sample table
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