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| Status |
Public on May 10, 2013 |
| Title |
Genome-wide analysis of Sox2-ablated optic cups compared with wild-type control optic cups at E16.5 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To test the hypothesis that ablation of the SOX2 in the developing optic cup leads to expansion of peripheral optic cup signaling pathways, we screened whole-genome changes in gene expression in Sox2-mutant eyes compared with controls. Results confirm that ciliary epithelial (peripheral) identity is gained at the expense of neural retinal identity in Sox2-ablated optic cups.
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| Overall design |
Total RNA was isolated from whole eyes enucleated from six wild-type controls and six Sox2-mutant embryos for a total of twelve eyes per genotype. Each embryo (pair of eyes) was analyzed as a single sample.
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| Contributor(s) |
Heavner W |
| Citation(s) |
25488119 |
| Submission date |
May 09, 2013 |
| Last update date |
Oct 01, 2019 |
| Contact name |
Whitney E Heavner |
| E-mail(s) |
whitney.heavner@nih.gov
|
| Organization name |
National Institutes of Health
|
| Department |
NINDS
|
| Lab |
Molecular Neurobiology Section
|
| Street address |
Building 35 Rm 2B-203
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA202307 |
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