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Series GSE4694 Query DataSets for GSE4694
Status Public on Apr 30, 2006
Title Expression data from myogenesis
Organism Mus musculus
Experiment type Expression profiling by array
Summary During muscle differentiation, myogenesis sepcific genes are differentially regulated, including Lamins that function at least in maintenance of nuclear architecture and regulation of gene expression.
We used microarrays to detail the global changes of gene expression in lamins and nuclear envelope assoicated proteins during myogenesis.
Keywords: comparative, myogenesis
Overall design C2C12 were cultured either in 20% serum (undifferentiated) or in 2% horse serum (differentiated). Differentiated C2C12 cells were harvested on day 6 after induction of myogenesis in low serum. Affymetirx microarray raw data were further processed by GCRMA to globally normalized signal values and then subjected to analysis of Bayesian regularized t-test. Gene expression, that has a p-value less than 0.05 in the t-test and has more than 1.5 fold change, was considered siginificant.
Contributor(s) Chen IB, Gerace L
Citation(s) 17062158, 19720741
Submission date Apr 20, 2006
Last update date Aug 28, 2019
Contact name Ihsiung Brandon Chen
Organization name The Scripps Research Institute
Department Cell Biology
Lab Larry Gerace
Street address 10550 N. Torrey Pines Rd.
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM106142 myoblast undifferentiated C2C12, biological rep1
GSM106143 myoblast undifferentiated C2C12, biological rep2
GSM106144 myoblast undifferentiated C2C12, biological rep3
BioProject PRJNA96741

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