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| Status |
Public on Sep 05, 2013 |
| Title |
miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Administration of mesenchymal stem cells (MSCs) has the potential to ameliorate degenerative disorders and to repair damaged tissues. The homing of transplanted MSCs to injured sites is a critical property of engraftment. Our aim was to identify microRNAs involved in controlling MSC proliferation and migration. MSCs can be isolated from bone marrow and umbilical cord Wharton's jelly (BM-MSCs and WJ-MSCs, respectively), and WJ-MSCs show poorer motility yet have a better amplification rate compared to BM-MSCs.
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| Overall design |
One human BM-MSC (pooled sample of 4 independent donors), one human WJ-MSC (pooled sample of 3 independent donors), and differentiated osteocytes and adipocytes derived from BM-MSCs after 2 weeks induction.
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| Contributor(s) |
Hsieh JY, Huang TS, Cheng SM, Lin WS, Tsai TN, Lee OK, Wang HW |
| Citation(s) |
23963696 |
| Submission date |
May 15, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Jui-Yu Hsieh |
| E-mail(s) |
juiyu.hsieh@gmail.com
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| Organization name |
National Yang-Ming University
|
| Street address |
No. 155, Sec 2, Li-Nong Street
|
| City |
Taipei |
| State/province |
--- |
| ZIP/Postal code |
112 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA203222 |
| SRA |
SRP022772 |
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