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Series GSE47154 Query DataSets for GSE47154
Status Public on Nov 04, 2013
Title Differential gene expression in peripheral blood leukocytes from mice subject to repeated social defeat
Organism Mus musculus
Experiment type Expression profiling by array
Summary This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood mononuclear cells (PBMC), and examined the extent to which these effects were abrogated by depletion of CD11b+ cells (monocytes).
Study Type: Risk prediction
Overall design Gene expression profiling was carried out on peripheral blood mononuclear cell (PBMC) mRNA samples collected from 18 mice randomized to either 6 cycles of repeated social defeat (RSD, n=9) or to home cage control (HCC, n=9) conditions. PBMC samples were pooled into 3 groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on approximately 1 million total PBMC and 1 million PBMC from which CD11b+ cells were immunomagnetically depleted by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether depletion of CD11b+ cells (monocytes) abrogates these effects.
Contributor(s) Cole S
Citation(s) 24062448
Submission date May 21, 2013
Last update date Jun 14, 2018
Contact name Steve Cole
Organization name UCLA School of Medicine
Department Medicine
Street address 11-934 Factor Bldg, UCLA
City Los Angeles
State/province CA
ZIP/Postal code 90095-1678
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (12)
GSM1145810 HCC TotalPBMC 1
GSM1145811 RSD TotalPBMC 1
GSM1145812 HCC CD11bNegPBMC 1
BioProject PRJNA204591

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47154_PBMCDecomp-QuantileNormGeneData.txt.gz 854.4 Kb (ftp)(http) TXT
GSE47154_PBMCDecomp-RawProbeData.txt.gz 1.2 Mb (ftp)(http) TXT
GSE47154_RAW.tar 3.1 Mb (http)(custom) TAR
Raw data are available on Series record
Processed data are available on Series record

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