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Series GSE47186 Query DataSets for GSE47186
Status Public on May 23, 2013
Title MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The biological significance of the down-regulation of miR-376c in HuCCT1 cells is unknown. We revealed that miR-376c significantly reduced EGF-dependent cell migration through its target GRB2 in HuCCT1 cells. To elucidate key molecules in EGF-dependent HuCCT1 migration, in which GRB2 upregulation is caused by abnormal suppression of miR-376c, we compared expression profiles of mRNAs affected by pre-miR-376c and siRNA targeting GRB2.
 
Overall design We compared expression profiles of mRNAs affected by pre-miR-376c and siRNA targeting GRB2 in EGF-treated HuCCT1 cells.
 
Contributor(s) Takizawa T
Citation(s) 23922722
Submission date May 22, 2013
Last update date Jan 09, 2018
Contact name Jun Iwaki
Organization name Nippon Medical School
Street address 1-1-5 Sendagi
City Bunkyo-ku
State/province Tokyo
ZIP/Postal code 113-8603
Country Japan
 
Platforms (1)
GPL13497 Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
Samples (4)
GSM1146430 CellStrain_siGRB2_24hEGF_rep1
GSM1146431 CellStrain_siControl_24hEGF_rep1
GSM1146432 CellStrain_mir-376c_24hEGF_rep1
Relations
BioProject PRJNA205046

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE47186_RAW.tar 8.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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