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Status |
Public on May 23, 2013 |
Title |
MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
The biological significance of the down-regulation of miR-376c in HuCCT1 cells is unknown. We revealed that miR-376c significantly reduced EGF-dependent cell migration through its target GRB2 in HuCCT1 cells. To elucidate key molecules in EGF-dependent HuCCT1 migration, in which GRB2 upregulation is caused by abnormal suppression of miR-376c, we compared expression profiles of mRNAs affected by pre-miR-376c and siRNA targeting GRB2.
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Overall design |
We compared expression profiles of mRNAs affected by pre-miR-376c and siRNA targeting GRB2 in EGF-treated HuCCT1 cells.
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Contributor(s) |
Takizawa T |
Citation(s) |
23922722 |
Submission date |
May 22, 2013 |
Last update date |
Jan 09, 2018 |
Contact name |
Jun Iwaki |
Organization name |
Nippon Medical School
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Street address |
1-1-5 Sendagi
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City |
Bunkyo-ku |
State/province |
Tokyo |
ZIP/Postal code |
113-8603 |
Country |
Japan |
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Platforms (1) |
GPL13497 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) |
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Samples (4)
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Relations |
BioProject |
PRJNA205046 |