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Series GSE4739 Query DataSets for GSE4739
Status Public on Jun 15, 2006
Title Temporal control of gene expression by ERK MAP kinase during cell cycle progression from G0/G1 to S phase
Organism Mus musculus
Experiment type Expression profiling by array
Summary The ERK family of MAP kinase plays a critical role in growth factor-stimulated cell cycle progression from G0/G1 to S phase. But, how sustained activation of ERK promotes G1 progression has remained unclear. Here, our systematic analysis on the temporal program of ERK-dependent gene expression shows that sustained activation of ERK is required for induction and maintenance of the decreased expression levels of a set of genes. Moreover, our cell biological analysis reveals that these ERK-dependent downregulated genes have the ability to block S phase entry. Cessation of ERK activation at mid or late G1 leads to a rapid increase of these anti-proliferative genes and results in the inhibition of S phase entry. These findings uncover an important mechanism by which the duration of ERK activation regulates cell cycle progression through dynamic changes in gene expression, and identify novel ERK target genes crucial for the regulation of cell cycle progression.
Keywords: time course
Overall design time points: 0h, 1h, 4h, 7h, 12h
Contributor(s) Yamamoto T, Ebisuya M, Ashida F, Nishida E
Citation(s) 16782007, 19160492
Submission date Apr 28, 2006
Last update date Feb 11, 2019
Contact name Eisuke Nishida
Phone +81-75-753-4230
Organization name Graduate School of Biostudies, Kyoto University
Department Department of Cell and Developmental Biology
Street address Kitashirakawa, Sakyo-ku
City Kyoto
ZIP/Postal code 606-8502
Country Japan
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (19)
GSM107391 NIH3T3_0h_exp1_rep1
GSM107392 NIH3T3_0h_exp1_rep2
GSM107393 NIH3T3_0h_exp2
BioProject PRJNA95679

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Supplementary file Size Download File type/resource
GSE4739_RAW.tar 89.0 Mb (http)(custom) TAR (of CEL)

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